Thom Tillis on "Face the Nation". Focus on "Fructose-induced leptin resistance exacerbates weight gain in response to subsequent high-fat feeding," by Shapiro et al". Basil Abramowitz "I try to exceed expectations in a kind and caring manner. In regard to the hormone leptin, central vs peripheral refers to the hypothalamic portion of the brain vs non-hypothalamic location of action of leptin; direct vs indirect refers to whether there is no intermediary, or there is an intermediary in the mode of action of leptin; and primary vs secondary is an arbitrary description of a particular function of leptin. In fetal lung, leptin is induced in the alveolar interstitial fibroblasts "lipofibroblasts" by the action of PTHrP secreted by formative alveolar epithelium endoderm under moderate stretch.
According to some studies in rats, it can inhibit a fat producing enzyme called Citrate Lyase, making it more difficult for the body to produce fat out of carbohydrates (1). Other rat studies show increased levels of the neurotransmitter serotonin.
This could theoretically lead to reduced appetite and cravings (2). There are actually a whole bunch of studies in rats showing that Garcinia Cambogia consistently leads to significant weight loss (3, 4, 5, 6).